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SAMD1 is a nuclear protein that binds to unmethylated CGIs. We recently found that the WH domains of the PCL proteins functions as a new type of unmethylated CGI-binding domains ().Thus, we speculated that there could be other unknown domains or proteins that regulate CGI function through direct interaction with the CpG motifs.


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To find the domain of a function, consider any restrictions on the input values that would make the function undefined, including dividing by zero, taking the square root of a negative number, or taking the logarithm of a negative number. Remove these values from the set of all possible input values to find the domain of the function.