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Human chorionic somatomammotropin (HCS), also known as human placental lactogen (HPL) is produced by the syncytiotrophoblast starting in week 6. HCS functions to promote breast development and decrease maternal insulin sensitivity and increases glucose availability for the fetus.. StatPearls Publishing; Treasure Island (FL): Dec 19, 2022.
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Human Placental Lactogen. Human placental lactogen (hPL) is a single-chain polypeptide of 191 amino acids. hPL is very similar to human growth hormone (GH) but has only 3% of its activity. Its lactogenic contribution in human pregnancy is uncertain. Its half-life is approximately 15 min. The hPL level in the maternal circulation is correlated.
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Prolactin is a polypeptide hormone that is responsible for lactation, breast development, and hundreds of other actions needed to maintain homeostasis. The chemical structures prolactin is similar to the structure of growth hormone and placental lactogen hormone. Together, they form the "prolactin/growth hormone/placental lactogen" family.
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Abstract. Placental lactogen and prolactin along with growth hormone form a family of protein hormones with striking homologies in chemical and biological properties (Josimovich and McLaren, 1962; Sherwood et al., 1971). The three hormones have molecular weights in the range of 22-24 kD and exhibit both lactogenic and somatotrophic properties.
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Human placental lactogen (hPL) is a placental hormone which appears to have key metabolic functions in pregnancy. Preclinical studies have putatively linked hPL to maternal and fetal outcomes, yet—despite human observational data spanning several decades—evidence on the role and importance of this hormone remains disparate and conflicting.
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Human Placental Lactogen. Human placental lactogen (hPL) is a placental protein hormone secreted by the synytiotrophoblast that rises steadily and peaks at 34 weeks of gestation. hPL shares structural homology with growth hormone (GH) and prolactin and can bind both receptors. In concert with human placental growth hormone (hPGH), hPL modulates.
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Placental lactogen (PL) is a peptide hormone secreted throughout pregnancy by both animal and human specialized endocrine cells. PL plays an important role in the regulation of insulin secretion in pancreatic β-cells, stimulating their proliferation and promoting the expression of anti-apoptotic proteins. Cases of pregnancy affected by.
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Gestational diabetes etiology is apparently related to 1) the pancreatic beta-cell dysfunction or the delayed response of the beta cells to the glycemic levels, and 2) the marked insulin resistance secondary to placental hormonal release. The human placental lactogen is the main hormone related to increased insulin resistance in GDM.
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During a pregnancy, human placental lactogen plays these key roles: Metabolism regulation. Human placental lactogen helps to regulate your metabolism, which is the use of fats and carbohydrates.
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Human placental lactogen is a hormone released by the placenta when you're pregnant. It helps prepare your body for breastfeeding. It also regulates metabolism and insulin sensitivity to make sure the fetus gets enough nutrients. A blood test can measure the hormone to help determine the health of the placenta, fetus and pregnant person.
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Human placental lactogen (hPL), also called human chorionic somatomammotropin (hCS) or human chorionic somatotropin, is a polypeptide placental hormone, the human form of placental lactogen (chorionic somatomammotropin). Its structure and function are similar to those of human growth hormone.It modifies the metabolic state of the mother during pregnancy to facilitate energy supply to the fetus.