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Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y₁₂ adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to.
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Multidrug therapy increases the risk for drug-drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y 12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in.
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Generic Name Clopidogrel DrugBank Accession Number DB00758 Background. Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. 3,9 Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or.
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Clopidogrel drug interactions: a review of the evidence and clinical implications. doi: 10.1080/17425255.2020.1814254. inhibitor, is a topic of potential clinical concern. This article reviews DDIs between clopidogrel and drugs which are widely used in clinical practice. In particular, drugs shown to interfere with the pharmacodynamic and.
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Key takeaways: Clopidogrel is a medication that prevents blood clots from forming. This can lower the risk of heart attack and stroke. Medications like proton pump inhibitors (PPIs), fluoxetine (Prozac), and fluconazole (Diflucan) can make clopidogrel less effective. Grapefruit juice can also make clopidogrel less effective.
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Plavix (clopidogrel bisulfate) is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Chemically it is methyl (+)-(S)-α (2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H.
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Defibrotide. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab. Aceclofenac. Acemetacin. Alfentanil.
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Clopidogrel may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure clopidogrel is right for you. This medicine is not expected to harm an unborn baby. However, taking clopidogrel within 1 week before childbirth can cause bleeding in the.
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It comes as a tablet taken by mouth once per day and is also available as a generic medication. Since it's a blood thinner, possible side effects include bleeding and bruising, especially if you take medications that interact with clopidogrel (Plavix) like certain antidepressants, anticoagulants, or non-steroidal anti-inflammatory drugs (NSAIDs).
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Clopidogrel Interactions. There are 249 drugs known to interact with clopidogrel, along with 3 disease interactions. Of the total drug interactions, 64 are major, 168 are moderate, and 17 are minor.
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Clopidogrel is FDA approved for the medical management of unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI), ST-segment elevation myocardial infarction (STEMI) in patients receiving fibrinolytic therapy, and for secondary prevention in recent myocardial infarction (MI), recent stroke, and peripheral arterial disease. There also a number of other FDA-approved uses.
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The DDI profiles of clopidogrel have been reviewed by Egan et al, Shah et al, Siller-Matula et al and Scott et al.7-10 However, these authors only addressed the circumstances under which DDIs occurred when clopidogrel was the object drug or focused on combination therapy with clopidogrel and special classes of medications, such as.
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Plavix is a P2Y12 platelet inhibitor indicated for: Acute coronary syndrome. For patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), Plavix has been shown to reduce the rate of myocardial infarction (MI) and stroke. (1.1)
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Clopidogrel (Plavix) Clopidogrel (Plavix®) is an antiplatelet drug you can take to prevent blood clots. It keeps platelets in your blood from coming together and making clots. You may need clopidogrel to prevent future issues if you had a heart attack, stroke or certain types of heart surgery. Additional Common Questions.
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Side Effects. Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that.
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The way clopidogrel works is thought to be due to its active thiol metabolite, which inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor which indirectly inhibits platelet aggregation. This action is irreversible. By inhibiting platelet aggregation, blood flows more freely around the body.